Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 2/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768270 | 0.89 | GPR34 (0.51) | MAPTNPSR1KDM4EMME | |
| SCHEMBL1768436 | 0.89 | GPR34 (0.51) | MAPTNPSR1KDM4EMME | |
| SCHEMBL7328548 | 0.83 | ITGA4 (0.53) | POLBTDP1MAPTNPSR1CTSS | |
| SCHEMBL10447913 | 0.83 | ITGA4 (0.53) | POLBTDP1MAPTNPSR1CTSS | |
| SCHEMBL7328544 | 0.83 | ITGA4 (0.53) | POLBTDP1MAPTNPSR1CTSS | |
| SCHEMBL27936341 | 0.82 | POLB (0.45) | POLBTACR1TDP1CTSSCTSK | |
| SCHEMBL1768282 | 0.81 | MME (0.62) | POLBPPARATDP1MAPTNPSR1 | |
| SCHEMBL1793637 | 0.81 | MME (0.62) | POLBPPARATDP1MAPTNPSR1 | |
| SCHEMBL1768280 | 0.81 | MME (0.62) | POLBPPARATDP1MAPTNPSR1 | |
| SCHEMBL15608113 | 0.81 | MME (0.54) | PPARGPPARATDP1CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011061271-A1 | SUBSTITUTED CARBAMOYLMETHYLAMINO ACETIC ACID DERIVATIVES AS NOVEL NEP INHIBITORS | NOVARTIS AG (CH) | 2011-05-26 | — | — | WO | disclosed |