Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841837 | 0.82 | RPS6KA3 (0.41) | KMT2AKDM4EMEN1ALDH1A1NPC1 | |
| SCHEMBL3244153 | 0.81 | SRD5A2 (0.43) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL4826623 | 0.78 | KMT2A (0.33) | KMT2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL3986116 | 0.74 | KMT2A (0.35) | KMT2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL3986119 | 0.74 | KMT2A (0.35) | KMT2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL1873666 | 0.72 | NOTUM (0.42) | KMT2AALDH1A1TSHRHTR2AHTR2C | |
| SCHEMBL2156291 | 0.70 | NOTUM (0.42) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2421457 | 0.69 | KDM4E (0.49) | KMT2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL241854 | 0.68 | SRD5A2 (0.39) | KMT2AKDM4EMEN1ALDH1A1MAPT | |
| Hydroxyamine SCHEMBL9656514 | 0.68 | NOTUM (0.39) | KMT2AKDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268643-B1 | DIOXOLANE AND DIOXOLANONE FUSED INDOLOBENZADIAZEPINE HCV NS5B INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-08-06 | — | — | EP | disclosed |
| US-8138171-B2 | Dioxolane and dioxolanone fused indolobenzadiazepine HCV NS5B inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-20 | — | — | US | disclosed |
| US-20110020277-A1 | Dioxolane and Dioxolanone Fused Indolobenzadiazepine HCV NS5B Inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110020277-A1 | Dioxolane and Dioxolanone Fused Indolobenzadiazepine HCV NS5B Inhibitors | SQLE, DHX15, FDFT1 | KMT2A 3261/4885KDM4E 1358/4885MEN1 4753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.