Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.42 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73285 | 1.00 | AHR (0.50) | AHRCYP1A2KCNH2HSD17B10FBP1 | |
| SCHEMBL9661512 | 0.81 | AHR (0.46) | AHRCYP1A2KCNH2HSD17B10FBP1 | |
| SCHEMBL9661520 | 0.81 | AHR (0.46) | AHRCYP1A2KCNH2HSD17B10FBP1 | |
| SCHEMBL6397551 | 0.78 | APP (0.52) | CYP1A2HSD17B10ALDH1A1KDM4EMAPT | |
| SCHEMBL3885395 | 0.78 | NFE2L2 (0.50) | FBP1GRIK1GRIK2PTGS1NFE2L2 | |
| SCHEMBL5230246 | 0.78 | CYP2C19 (0.42) | ALDH1A1KDM4EMAPTGRIK1GRIK2 | |
| SCHEMBL11699628 | 0.78 | AHR (0.48) | AHRCYP1A2KCNH2HSD17B10FBP1 | |
| SCHEMBL73226 | 0.78 | NFE2L2 (0.50) | FBP1GRIK1GRIK2PTGS1NFE2L2 | |
| SCHEMBL2093401 | 0.78 | CYP1A2 (0.50) | AHRCYP1A2KCNH2HSD17B10FBP1 | |
| SCHEMBL2080531 | 0.78 | AHR (0.48) | AHRCYP1A2KCNH2HSD17B10FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515969-B2 | SPIROINDOLINEPIPERIDINE DERIVATIVES | SYNGENTA LTD (GB) | 2017-10-11 | — | — | EP | disclosed |
| US-9686990-B2 | Spiroindolinepiperidine derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2017-06-27 | — | — | US | disclosed |
| US-20160007608-A1 | SPIROINDOLINEPIPERIDINE DERIVATIVES | SYNGENTA LIMITED (GB) | 2016-01-14 | — | — | US | disclosed |
| US-9174987-B2 | Spiroindolinepiperidine derivatives | SYNGENTA LIMITED (DE) | 2015-11-03 | — | — | US | disclosed |
| US-9045422-B2 | Piperidine derivatives with pesticidal properties | SYNGENTA PARTICIPATIONS AG (CH) | 2015-06-02 | — | — | US | disclosed |
| EP-1880996-B1 | SPIROINDOLINEPIPERIDINE DERIVATIVES | SYNGENTA LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-8846907-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2014-09-30 | — | — | US | disclosed |
| US-8796274-B2 | Piperazine derivatives and their use in controlling pests | SYNGENTA CROP PROTECTION LLC (US) | 2014-08-05 | — | — | US | disclosed |
| US-20140179921-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2014-06-26 | — | — | US | disclosed |
| EP-1755396-B1 | PIPERAZIN DERIVATIVES AND THEIR USE IN CONTROLLING PESTS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| EP-0226636-A1 | NEW CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURING PROCESS, USE AND MEDICINES CONTAINING THESE COMPOUNDS. | BOEHRINGER MANNHEIM GMBH (DE) | 1987-07-01 | — | — | EP | disclosed |
| EP-0221344-A1 | Sulphonyl-phenyl alkyl amines, process for their preparation and medicines | Roche Diagnostics GmbH (DE) | 1987-05-13 | — | — | EP | disclosed |
| EP-0211457-A2 | Novel (4-substituted-piperazinyl)pyridazines | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-02-25 | — | — | EP | disclosed |
| WO-1987000521-A2 | NEW CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURING PROCESS, USE AND MEDICINES CONTAINING THESE COMPOUNDS | BOEHRINGER MANNHEIM GMBH (DE) | 1987-01-29 | — | — | WO | disclosed |
| CN-86105558-A | The preparation method of new (4-replaces-piperazinyl) pyridazine class | — | 1987-01-28 | — | — | CN | disclosed |
| US-4616086-A | ANTICOAGULANTS | BOEHRINGER MANNHEIM GMBH (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0183212-A2 | Pyridazinone derivatives, preparation thereof, and insecticidal, acaricidal, nematicidal, fungicidal compositions | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-06-04 | — | — | EP | disclosed |
| EP-0076996-B1 | CARBOXYLIC-ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1986-01-02 | — | — | EP | disclosed |
| EP-0076996-A1 | Carboxylic-acid derivatives, process for their preparation and medicines containing them | Roche Diagnostics GmbH (DE) | 1983-04-20 | — | — | EP | disclosed |
| US-4335055-A | Process for the preparation of alkenylbenzene derivatives or alkenylnaphthalene derivatives | CIBA-GEIGY CORPORATION (US) | 1982-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179921-A1 | CHEMICAL COMPOUNDS | H1-0, REL, ZYX | AHR 405/4885CYP1A2 338/4885KCNH2 378/4885 |
| US-20160007608-A1 | SPIROINDOLINEPIPERIDINE DERIVATIVES | RECQL, OPRD1, SKP1 | AHR 2421/4885CYP1A2 479/4885KCNH2 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.