Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.70 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.60 |
| ▸ | CDK9 | P50750 | 1/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.60 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.60 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | ULK1 | O75385 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15759024 | 0.88 | MAP3K11 (0.60) | MAP3K11DYRK3CCNT1CDK9CDK5 | |
| SCHEMBL7089345 | 0.88 | MAP3K11 (0.56) | MAP3K11DYRK3CCNT1CDK9CDK5 | |
| SCHEMBL2522333 | 0.88 | MAP3K11 (0.80) | MAP3K11DYRK3CCNT1CDK9CDK5 | |
| SCHEMBL721794 | 0.83 | MAP3K11 (1.00) | MAP3K11DYRK1ADYRK2DYRK1BLRRK2 | |
| SCHEMBL414175 | 0.82 | BRD4 (0.63) | MAP3K11DYRK3CDK5DYRK1ADYRK1B | |
| SCHEMBL31735806 | 0.82 | DYRK1A (0.53) | MAP3K11DYRK3CCNT1CDK9CDK5 | |
| SCHEMBL12680497 | 0.81 | NPC1 (0.56) | MAP3K11DYRK1ADYRK2DYRK1BNPC1 | |
| SCHEMBL7273777 | 0.78 | LOXL2 (0.61) | MAP3K11LOXL2PDGFRBPDGFRAHSD17B1 | |
| SCHEMBL1149903 | 0.77 | MAP3K11 (0.47) | MAP3K11DYRK3CCNT1CDK9CDK5 | |
| SCHEMBL29547936 | 0.77 | MAP3K11 (0.47) | MAP3K11DYRK3CCNT1CDK9CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674620-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014771-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |