Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 5/20 | 0.34 |
| ▸ | METAP1 | P53582 | 3/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14415382 | 0.79 | REN (0.45) | RENKMT2AMETAP2METAP1 | |
| SCHEMBL14420284 | 0.79 | REN (0.45) | RENKMT2AMETAP2METAP1 | |
| SCHEMBL7361324 | 0.79 | REN (0.45) | RENKMT2AMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7441478 | 0.78 | REN (0.44) | RENMETAP2METAP1 | |
| SCHEMBL7326084 | 0.77 | REN (0.52) | RENALDH1A1KMT2AMETAP2METAP1 | |
| SCHEMBL7328910 | 0.77 | REN (0.52) | RENALDH1A1KMT2AMETAP2METAP1 | |
| SCHEMBL8682141 | 0.77 | REN (0.55) | RENALDH1A1KMT2AMETAP2METAP1 | |
| SCHEMBL7279876 | 0.77 | REN (0.55) | RENALDH1A1KMT2AMETAP2METAP1 | |
| SCHEMBL8682444 | 0.77 | REN (0.55) | RENALDH1A1KMT2AMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7324277 | 0.76 | REN (0.51) | RENALDH1A1KMT2AMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0380805-A1 | Renin inhibitors containing C-terminal dihydroxy amides | WARNER-LAMBERT COMPANY (US) | 1990-08-08 | — | — | EP | disclosed |
| WO-1990007521-A1 | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |