Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.45 |
| ▸ | METAP2 | P50579 | 11/20 | 0.39 |
| ▸ | METAP1 | P53582 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14420284 | 1.00 | REN (0.45) | RENMETAP2METAP1MEN1KMT2A | |
| SCHEMBL14415382 | 1.00 | REN (0.45) | RENMETAP2METAP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7441478 | 0.98 | REN (0.44) | RENMETAP2METAP1 | |
| SCHEMBL7328807 | 0.79 | REN (0.45) | RENMETAP2METAP1KMT2A | |
| SCHEMBL7264762 | 0.78 | METAP2 (0.41) | RENMETAP2METAP1MEN1KMT2A | |
| SCHEMBL7266597 | 0.78 | METAP2 (0.41) | RENMETAP2METAP1MEN1KMT2A | |
| SCHEMBL7440383 | 0.78 | REN (0.40) | RENMETAP2METAP1 | |
| SCHEMBL7444603 | 0.78 | METAP2 (0.44) | RENMETAP2METAP1 | |
| SCHEMBL7277378 | 0.78 | REN (0.47) | RENMETAP2METAP1 | |
| SCHEMBL7279876 | 0.77 | REN (0.55) | RENMETAP2METAP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415981-A4 | RETROVIRAL PROTEASE INHIBITORS | — | 1991-10-09 | — | — | EP | disclosed |
| EP-0415981-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |
| WO-1989010752-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |
| US-4645759-A | HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1987-02-24 | — | — | US | disclosed |
| EP-0172347-A2 | Renin inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-02-26 | — | — | EP | disclosed |