Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295021 | 0.89 | ADRB2 (0.33) | LMNA | |
| SCHEMBL7303881 | 0.88 | LMNA (0.35) | LMNAKMT2AATMCYP4F2CYP4A11 | |
| SCHEMBL11433356 | 0.86 | LMNA (0.34) | LMNAKMT2AATM | |
| SCHEMBL7299847 | 0.82 | MEN1 (0.33) | LMNAKMT2A | |
| SCHEMBL7336623 | 0.79 | ADRB2 (0.46) | LMNAKMT2A | |
| SCHEMBL252046 | 0.78 | IDO1 (0.33) | — | |
| SCHEMBL92354 | 0.78 | CA1 (0.44) | ATM | |
| SCHEMBL1166414 | 0.77 | HPGD (0.33) | ATM | |
| SCHEMBL14499021 | 0.77 | CYP1A2 (0.46) | — | |
| SCHEMBL7328315 | 0.76 | KCNH2 (0.30) | LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0234776-B1 | PROCESS FOR 1,4-DIHYDROPYRIDINE COMPOUNDS | MERCK & CO. INC. (US) | 1991-09-04 | — | — | EP | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |
| US-4780538-A | REACTING AN AMINOALKENOATE WITH AN AROMATIC ALDEHYDE USING AN TITANAMINE CATALYST | MERCK & CO., INC. (US) | 1988-10-25 | — | — | US | disclosed |
| EP-0234776-A2 | Process for 1,4-dihydropyridine compounds | MERCK & CO. INC. (US) | 1987-09-02 | — | — | EP | disclosed |
| US-4567268-A | Process for preparation of certain tetrahydrofuro[3,4-b]pyridines | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |