Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 6/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.46 |
| ▸ | HTR3B | O95264 | 4/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333639 | 0.95 | HTR3A (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7330468 | 0.88 | HTR3A (0.43) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7326370 | 0.84 | HTR3A (0.42) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7335821 | 0.80 | HTR3A (0.40) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7408561 | 0.76 | HTR3A (0.44) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7313164 | 0.73 | HTR3A (0.41) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7314442 | 0.73 | HTR3A (0.41) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7328897 | 0.71 | HTR3A (0.65) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7410976 | 0.71 | ACHE (0.43) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7333634 | 0.71 | HTR3A (0.65) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920227-A | Benzobicyclic carboxamide 5-HT3 antagonists | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |