Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.39 |
| ▸ | FAAH | O00519 | 8/20 | 0.39 |
| ▸ | CES1 | P23141 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5523415 | 0.86 | FFAR1 (0.43) | CES2LPAR1LPAR3 | |
| SCHEMBL7825586 | 0.79 | CES2 (0.43) | CES2FAAHCES1MEN1CYP1A2 | |
| SCHEMBL7825590 | 0.79 | CES2 (0.43) | CES2FAAHCES1MEN1CYP1A2 | |
| SCHEMBL20047449 | 0.78 | CES2 (0.48) | CES2FAAHCES1MEN1CYP1A2 | |
| SCHEMBL28653124 | 0.77 | AKR1B1 (0.37) | MEN1KMT2AHSD17B10AKR1B1 | |
| SCHEMBL1114580 | 0.77 | ACLY (0.38) | MEN1KMT2AHSD17B10AKR1B1 | |
| SCHEMBL20047566 | 0.77 | ACLY (0.39) | FAAHMEN1CYP1A2KMT2A | |
| SCHEMBL6909109 | 0.76 | AKR1B1 (0.36) | MEN1KMT2AHSD17B10AKR1B1 | |
| SCHEMBL29275052 | 0.76 | ACLY (0.36) | MEN1KMT2AHSD17B10AKR1B1 | |
| SCHEMBL23502535 | 0.75 | CES2 (0.50) | CES2FAAHCES1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610439-B1 | PYRIMIDOCYCLOALKANES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PROD (US) | 1999-12-15 | — | — | EP | disclosed |
| EP-0610439-A1 | PYRIMIDOCYCLOALKANES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5234936-A | Treating hypertension, congestive heart failure, hyperlipidemia and hypercholesterolemia | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-10 | — | — | US | disclosed |
| WO-1993008171-A1 | PYRIMIDOCYCLOALKANES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-29 | — | — | WO | disclosed |