Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 11/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.56 |
| ▸ | CYP17A1 | P05093 | 5/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953768 | 0.82 | CYP2A6 (0.65) | CYP11B2CYP11B1CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL30338584 | 0.81 | CYP11B2 (0.65) | CYP11B2CYP11B1CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL7953760 | 0.80 | NPY5R (0.51) | CYP11B2CYP11B1CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL29566706 | 0.80 | CYP11B2 (0.73) | CYP11B2CYP11B1CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL792083 | 0.80 | CYP11B2 (0.73) | CYP11B2CYP11B1CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL29419006 | 0.80 | CYP11B2 (0.63) | CYP11B2CYP11B1CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL732632 | 0.79 | CYP1A1 (0.45) | CYP11B2CYP11B1CYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL2224174 | 0.78 | CYP2A6 (0.54) | CYP11B2CYP11B1CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL9957709 | 0.78 | CYP2A6 (0.58) | CYP11B2CYP11B1CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL7955909 | 0.76 | CYP2A6 (0.56) | CYP11B2CYP11B1CYP17A1CYP19A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-B1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | disclosed |
| US-8138197-B2 | Spirochromanon derivatives | MSD K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| EP-2120569-A2 | SPIROCHROMANON DERIVATIVES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME LLC | 2009-10-29 | — | — | US | disclosed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | AKR1C3, CBR3, AKR1C4 | CYP11B2 178/4885CYP11B1 106/4885CYP17A1 626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.