Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.57 |
| ▸ | RAD52 | P43351 | 1/20 | 0.57 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.57 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | PTAFR | P25105 | 9/20 | 0.43 |
| ▸ | EED | O75530 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479084 | 0.81 | DNMT1 (0.57) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL10822596 | 0.76 | GAA (0.55) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL10822501 | 0.75 | DNMT1 (0.49) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL10822386 | 0.74 | MEN1 (0.50) | DNMT1RAD52UHRF1ADORA3 | |
| SCHEMBL2493946 | 0.73 | DNMT1 (0.62) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL10822558 | 0.72 | PTAFR (0.51) | DNMT1RAD52UHRF1PTAFRMAOA | |
| SCHEMBL10822612 | 0.72 | DNMT1 (0.46) | DNMT1RAD52UHRF1PTAFRADORA3 | |
| SCHEMBL9414799 | 0.70 | DNMT1 (0.44) | DNMT1RAD52UHRF1CA1CA2 | |
| SCHEMBL10822981 | 0.70 | ALDH1A1 (0.46) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL10822548 | 0.69 | SCN2A (0.53) | DNMT1RAD52UHRF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491814-B1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NOVO NORDISK AS (DK) | 1995-12-06 | — | — | EP | disclosed |
| EP-0491814-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS. | NOVO NORDISK AS (DK) | 1992-07-01 | — | — | EP | disclosed |
| US-5100895-A | Imidazoquinazoline compounds; anticonvulsants, anxiolytics, hypnotics, antipsychotics, antiemetics, improving cognitive function | NOVO NORDISK A/S (DK) | 1992-03-31 | — | — | US | disclosed |
| WO-1991003478-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NOVO NORDISK A/S (DK) | 1991-03-21 | — | — | WO | disclosed |
| EP-0417027-A1 | Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | NOVO NORDISK A/S (DK) | 1991-03-13 | — | — | EP | disclosed |