Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.62 |
| ▸ | PPARA | Q07869 | 3/20 | 0.57 |
| ▸ | PPARD | Q03181 | 2/20 | 0.57 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9480783 | 0.84 | NR1H3 (0.66) | KMT2AMEN1NR1H3PPARAPPARD | |
| SCHEMBL4649471 | 0.83 | KMT2A (0.78) | KMT2AMEN1NR1H3PPARAPPARD | |
| SCHEMBL30758581 | 0.81 | NR1H3 (0.62) | KMT2AMEN1NR1H3PPARAPPARD | |
| SCHEMBL13412864 | 0.81 | NR1H3 (0.62) | KMT2AMEN1NR1H3PPARAPPARD | |
| SCHEMBL4594655 | 0.81 | NR1H3 (0.62) | KMT2AMEN1NR1H3PPARAPPARD | |
| SCHEMBL2688855 | 0.81 | NR1H3 (0.62) | KMT2AMEN1NR1H3PPARAPPARD | |
| Bromide SCHEMBL4875685 | 0.79 | NR1H3 (0.60) | KMT2AMEN1NR1H3PPARAPPARD | |
| SCHEMBL7443516 | 0.79 | NR1H3 (0.59) | KMT2AMEN1NR1H3PPARAPPARD | |
| SCHEMBL9053599 | 0.78 | CASP3 (0.65) | KMT2AMEN1CA9CA12CA1 | |
| SCHEMBL12076522 | 0.78 | NR1H3 (0.73) | KMT2AMEN1NR1H3PPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5075304-A | Nervous system disorders | NOVO NORDISK A/S (DK) | 1991-12-24 | — | — | US | disclosed |
| US-4999353-A | Chemical process for the preparation of imidazo-quinoxalines and intermediates for use in the process | NOVO NORDISK A/S (DK) | 1991-03-12 | — | — | US | disclosed |
| EP-0368652-A1 | Imidazoquinoxalines and their preparation | NOVO NORDISK A/S (DK) | 1990-05-16 | — | — | EP | disclosed |
| EP-0344943-A1 | Imidazoquinoxaline compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1989-12-06 | — | — | EP | disclosed |