Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSPO | P30536 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805159 | 0.75 | HSD17B10 (0.65) | HSD17B10ALDH1A1MEN1KMT2AMTNR1A | |
| SCHEMBL6180298 | 0.73 | KMT2A (0.41) | ALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL7324343 | 0.72 | CA12 (0.42) | HSD17B10ALDH1A1HIF1ATAAR1POLB | |
| SCHEMBL6724746 | 0.71 | HSD17B10 (0.56) | HSD17B10MEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL6724742 | 0.71 | HSD17B10 (0.56) | HSD17B10MEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL8468532 | 0.71 | SLC6A4 (0.54) | HSD17B10ADRA1ATAAR1IDO1 | |
| SCHEMBL11160909 | 0.70 | HSD17B10 (0.55) | HSD17B10MEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL687106 | 0.69 | KDM4E (0.53) | HSD17B10ALDH1A1POLB | |
| SCHEMBL7323219 | 0.69 | GABRA1 (0.39) | HSD17B10ALDH1A1KMT2A | |
| SCHEMBL1805352 | 0.69 | PPARG (0.43) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |