Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 6/20 | 0.42 |
| ▸ | FNTB | P49356 | 6/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329495 | 0.89 | LTA4H (0.48) | LTA4HMMEANPEPFNTAFNTB | |
| SCHEMBL7334299 | 0.87 | MME (0.47) | MME | |
| SCHEMBL7338208 | 0.86 | — | — | |
| SCHEMBL7338166 | 0.84 | LTA4H (0.49) | LTA4HMMEANPEPFNTAFNTB | |
| SCHEMBL7339533 | 0.84 | LTA4H (0.48) | LTA4HMMEANPEPFNTAFNTB | |
| SCHEMBL7333546 | 0.81 | LTA4H (0.46) | LTA4HMMEANPEPFNTAFNTB | |
| SCHEMBL7339309 | 0.81 | LTA4H (0.46) | LTA4HMMEANPEPFNTAFNTB | |
| SCHEMBL7337459 | 0.78 | CYP1A2 (0.44) | — | |
| SCHEMBL7327334 | 0.76 | FNTA (0.62) | LTA4HMMEFNTAFNTBPGGT1B | |
| SCHEMBL7447698 | 0.76 | FNTA (0.62) | LTA4HMMEFNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |