Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324173 | 0.92 | TP53 (0.46) | KCNH2DRD2KDM1AADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL7324649 | 0.85 | KCNH2 (0.44) | KCNH2KDM1AADRB2ADRB1ADRB3 | |
| Hydrochloric Acid SCHEMBL7330177 | 0.85 | APLNR (0.44) | KCNH2KDM1AKDM4EAPAF1MAPT | |
| Toborinone SCHEMBL29856392 | 0.82 | ADRB3 (0.49) | KCNH2ADRB2ADRB1ADRB3KDM4E | |
| Toborinone SCHEMBL563955 | 0.82 | ADRB3 (0.49) | KCNH2ADRB2ADRB1ADRB3KDM4E | |
| Toborinone SCHEMBL7322759 | 0.82 | ADRB3 (0.49) | KCNH2ADRB2ADRB1ADRB3KDM4E | |
| SCHEMBL6650940 | 0.82 | KDM4E (0.47) | KCNH2KDM1AADRB2ADRB1ADRB3 | |
| SCHEMBL7375804 | 0.82 | KDM4E (0.47) | KCNH2KDM1AADRB2ADRB1ADRB3 | |
| SCHEMBL7329866 | 0.82 | KDM4E (0.47) | KCNH2KDM1AADRB2ADRB1ADRB3 | |
| SCHEMBL7321692 | 0.82 | KCNH2 (0.46) | KCNH2KDM1AADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5385914-A | Cardiotonic carbostyril agents for treating heart ailments | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-01-31 | — | — | US | disclosed |
| EP-0355583-B1 | Cardiotonics | OTSUKA PHARMA CO LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5266577-A | Method of treating congestive heart failure using carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY LTD. (JP) | 1993-11-30 | — | — | US | disclosed |
| US-5198448-A | Cardiovascular disorders | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1993-03-30 | — | — | US | disclosed |
| US-5053514-A | Side effect reduction; carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0355583-A2 | Cardiotonics | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-02-28 | — | — | EP | disclosed |