Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329094 | 0.85 | AURKA (0.49) | RHEBMAP4K4PIK3CDPARP1AURKA | |
| SCHEMBL7334380 | 0.82 | PRKAB2 (0.38) | RHEBPRKAA1PIK3CDNPC1PARP1 | |
| SCHEMBL7336629 | 0.82 | NR4A2 (0.45) | RHEBPIK3CDPARP1MEN1KMT2A | |
| SCHEMBL12313785 | 0.80 | CYP2A6 (0.50) | MEN1KMT2ARXFP1CYP2A6CSNK2A1 | |
| SCHEMBL18171651 | 0.78 | PRKCQ (0.42) | RHEBJAK2PRKCQIKBKBCHUK | |
| SCHEMBL7333681 | 0.78 | PRKCQ (0.48) | RHEBJAK2PRKCQIKBKBCHUK | |
| SCHEMBL16341336 | 0.77 | AHR (0.50) | RHEBPIK3CDPARP1KMT2ADRD4 | |
| SCHEMBL29712113 | 0.75 | PIK3CD (0.70) | RHEBJAK2PRKCQIKBKBCHUK | |
| SCHEMBL2193011 | 0.75 | PIK3CD (0.70) | RHEBJAK2PRKCQIKBKBCHUK | |
| SCHEMBL28889117 | 0.74 | PIK3CD (0.54) | RHEBJAK2PRKCQIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674620-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| CN-1092765-A | New tryptamine analogues and preparation method thereof and purposes | SMITHKLINE BEECHAM PLC (GB) | 1994-09-28 | — | — | CN | disclosed |
| WO-1994014771-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |