Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | RHEB | Q15382 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329094 | 0.86 | AURKA (0.49) | NR4A2PARP1AHRRHEBAURKA | |
| SCHEMBL7334380 | 0.83 | PRKAB2 (0.38) | PARP1RHEBAURKATPX2PIK3CD | |
| SCHEMBL7330190 | 0.82 | RHEB (0.46) | PARP1AHRRHEBAURKATPX2 | |
| SCHEMBL6322152 | 0.75 | PIK3CD (0.64) | NR4A2MAPK14GCGRAHRTRPA1 | |
| SCHEMBL8959626 | 0.74 | TNF (0.48) | NR4A2PARP1AHRTRPA1RHEB | |
| SCHEMBL30173343 | 0.72 | AXL (0.53) | MAPK14GCGRTRPA1MAPK1CSNK1D | |
| SCHEMBL28598985 | 0.72 | AXL (0.53) | MAPK14GCGRTRPA1MAPK1CSNK1D | |
| SCHEMBL7326270 | 0.70 | MAP3K11 (0.49) | MAPTMAPK1 | |
| SCHEMBL19211220 | 0.69 | TNKS2 (0.44) | AHRMEN1KMT2A | |
| SCHEMBL31403115 | 0.69 | BRD4 (0.52) | NR4A2MAPK14GCGRTRPA1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674620-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| CN-1092765-A | New tryptamine analogues and preparation method thereof and purposes | SMITHKLINE BEECHAM PLC (GB) | 1994-09-28 | — | — | CN | disclosed |
| WO-1994014771-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |