Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.49 |
| ▸ | PLAU | P00749 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326457 | 0.93 | ITGB3 (0.56) | ITGB3ITGA2BF10F2ITGA2 | |
| Acetic Acid SCHEMBL7331206 | 0.90 | ITGB3 (0.56) | ITGB3ITGA2BF10F2ITGA2 | |
| SCHEMBL9317817 | 0.90 | ITGB3 (0.51) | ITGB3ITGA2BF10F2PRSS1 | |
| Acetic Acid SCHEMBL7334578 | 0.87 | ITGB3 (0.60) | ITGB3ITGA2BMEN1KMT2AKHK | |
| SCHEMBL7332811 | 0.86 | CNR1 (0.42) | ITGB3ITGA2BMEN1KMT2AITGA2 | |
| SCHEMBL9317712 | 0.85 | ITGB3 (0.57) | ITGB3ITGA2BF10F2 | |
| Acetic Acid SCHEMBL9317585 | 0.83 | ITGB3 (0.57) | ITGB3ITGA2BF10F2 | |
| SCHEMBL7331720 | 0.83 | ITGB3 (0.67) | ITGB3ITGA2BF10F2PRSS1 | |
| SCHEMBL7323790 | 0.82 | ITGB3 (0.45) | ITGB3ITGA2BF10F2ITGA2 | |
| SCHEMBL7328382 | 0.82 | ITGB3 (0.47) | ITGB3ITGA2BMEN1KMT2AITGA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674863-A | BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR | GENENTECH, INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5674865-A | BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR | GENENTECH, INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5663166-A | ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING | GENENTECH, INC. (US) | 1997-09-02 | — | — | US | disclosed |
| US-5565449-A | PLATELET AGGREGATION INHIBITORS | GENENTECH, INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0610334-B1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR | GENENTECH INC (US) | 1996-01-24 | — | — | EP | disclosed |
| WO-1993008174-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1993-04-29 | — | — | WO | disclosed |