Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 11/20 | 0.46 |
| ▸ | EDNRA | P25101 | 8/20 | 0.45 |
| ▸ | EDNRB | P24530 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325135 | 0.89 | EDNRA (0.44) | DHPSEDNRAEDNRBLMNAHTT | |
| SCHEMBL7296639 | 0.86 | LMNA (0.39) | DHPSLMNAHTT | |
| SCHEMBL8322002 | 0.84 | EDNRA (0.46) | DHPSEDNRAEDNRBLMNAHTT | |
| SCHEMBL7322839 | 0.83 | EDNRA (0.42) | DHPSEDNRAEDNRB | |
| SCHEMBL7330749 | 0.83 | EDNRA (0.49) | DHPSEDNRAEDNRB | |
| SCHEMBL7333240 | 0.83 | EDNRA (0.50) | DHPSEDNRAEDNRB | |
| SCHEMBL7329858 | 0.82 | EDNRA (0.62) | DHPSEDNRAEDNRB | |
| SCHEMBL7327055 | 0.81 | EDNRA (0.48) | DHPSEDNRAEDNRB | |
| SCHEMBL7327165 | 0.80 | EDNRA (0.53) | DHPSEDNRAEDNRB | |
| SCHEMBL8326014 | 0.79 | EDNRA (0.39) | DHPSEDNRAEDNRBLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | claimed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | claimed |
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |