Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 12/20 | 0.46 |
| ▸ | EDNRB | P24530 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DHPS | P49366 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330283 | 0.84 | DHPS (0.46) | EDNRAEDNRBLMNAHTTDHPS | |
| SCHEMBL8322432 | 0.84 | LMNA (0.41) | EDNRAGAALMNAHTTDHPS | |
| SCHEMBL8324860 | 0.81 | EDNRA (0.60) | EDNRAEDNRBMEN1KMT2A | |
| SCHEMBL7330749 | 0.81 | EDNRA (0.49) | EDNRAEDNRBDHPS | |
| SCHEMBL7333240 | 0.81 | EDNRA (0.50) | EDNRAEDNRBDHPS | |
| SCHEMBL7329858 | 0.80 | EDNRA (0.62) | EDNRAEDNRBDHPS | |
| SCHEMBL7295229 | 0.80 | EDNRA (0.37) | EDNRAEDNRBGAALMNAHTT | |
| SCHEMBL7327055 | 0.79 | EDNRA (0.48) | EDNRAEDNRBDHPS | |
| SCHEMBL7322839 | 0.79 | EDNRA (0.42) | EDNRAEDNRBGAADHPSMEN1 | |
| SCHEMBL7327165 | 0.78 | EDNRA (0.53) | EDNRAEDNRBDHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |