Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331812 | 0.83 | CETP (0.47) | CETPTSHR | |
| SCHEMBL14890455 | 0.82 | CETP (0.50) | CETPTSHRSIGMAR1 | |
| SCHEMBL8658558 | 0.78 | CETP (0.45) | CETPTSHR | |
| SCHEMBL8729220 | 0.77 | TSHR (0.55) | CETPTSHRL3MBTL1SIGMAR1S1PR2 | |
| SCHEMBL7379497 | 0.76 | CETP (0.47) | CETPTSHRS1PR2S1PR4S1PR1 | |
| SCHEMBL10936592 | 0.75 | CETP (0.46) | CETPTSHRALOX5 | |
| SCHEMBL10890173 | 0.75 | MAPT (0.51) | CETPTSHRALOX5 | |
| SCHEMBL10895150 | 0.75 | CETP (0.40) | CETPTSHRL3MBTL1SIGMAR1S1PR2 | |
| SCHEMBL7434180 | 0.74 | TSHR (0.61) | CETPTSHRL3MBTL1S1PR2S1PR4 | |
| SCHEMBL5248630 | 0.74 | CETP (0.47) | CETPTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4598071-A | ANGIOTENSIN INHIBITORS/ | E. R. SQUIBB & SONS, INC. (US) | 1986-07-01 | — | — | US | disclosed |
| US-4567167-A | INHIBITOR OF ANGIOTENDIN CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4533661-A | Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity | E. R. SQUIBB & SONS, INC. (US) | 1985-08-06 | — | — | US | disclosed |