Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | ACP3 | P15309 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84477 | 0.82 | P2RX7 (0.50) | P2RX7ACP3HSD11B1CNR2MC4R | |
| SCHEMBL8917833 | 0.82 | ACP3 (0.46) | P2RX7ACP3HSD11B1CNR2MC4R | |
| SCHEMBL24816452 | 0.80 | TSHR (0.43) | P2RX7TDP1ALDH1A1 | |
| SCHEMBL2588201 | 0.78 | P2RX7 (0.47) | P2RX7ACP3HSD11B1CNR2MC4R | |
| SCHEMBL2224459 | 0.78 | P2RX7 (0.47) | P2RX7ACP3HSD11B1CNR2MC4R | |
| SCHEMBL1258401 | 0.78 | P2RX7 (0.47) | P2RX7ACP3HSD11B1CNR2MC4R | |
| SCHEMBL13168657 | 0.78 | ACP3 (0.47) | P2RX7ACP3HSD11B1CNR2MC4R | |
| SCHEMBL23172133 | 0.78 | P2RX7 (0.47) | P2RX7ACP3HSD11B1CNR2MC4R | |
| SCHEMBL13537951 | 0.78 | P2RX7 (0.47) | P2RX7ACP3HSD11B1CNR2MC4R | |
| SCHEMBL1727762 | 0.78 | P2RX7 (0.47) | P2RX7ACP3HSD11B1CNR2MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |