SCHEMBL8917833

SCHEMBL8917833

FC(F)(F)c1ccccc1C(I)I

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACP3 P15309 1/20 0.46
P2RX7 Q99572 1/20 0.41
CNR2 P34972 2/20 0.41
ALDH1A1 P00352 1/20 0.39
POLB P06746 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
IDO1 P14902 3/20 0.39
TDO2 P48775 1/20 0.39
CA2 P00918 1/20 0.36
MC4R P32245 1/20 0.36
OPRM1 P35372 1/20 0.36
OPRD1 P41143 1/20 0.36
OPRK1 P41145 1/20 0.36
OPRL1 P41146 1/20 0.36
NOTUM Q6P988 1/20 0.36
HSD11B1 P28845 2/20 0.36
CNR1 P21554 1/20 0.35
LMNA P02545 1/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7330369 0.82 P2RX7 (0.47) ACP3P2RX7CNR2ALDH1A1POLB
SCHEMBL10546400 0.78 ACP3 (0.47) ACP3P2RX7CNR2ALDH1A1POLB
SCHEMBL29523337 0.76 ACP3 (0.46) ACP3P2RX7CNR2ALDH1A1POLB
SCHEMBL30903830 0.76 ACP3 (0.50) ACP3P2RX7CNR2ALDH1A1POLB
SCHEMBL30705308 0.76 P2RX7 (0.50) ACP3P2RX7CNR2ALDH1A1POLB
SCHEMBL9776265 0.76 ACP3 (0.50) ACP3P2RX7CNR2ALDH1A1POLB
SCHEMBL9242031 0.76 P2RX7 (0.50) ACP3P2RX7CNR2ALDH1A1POLB
SCHEMBL84477 0.76 P2RX7 (0.50) ACP3P2RX7CNR2ALDH1A1POLB
SCHEMBL7570359 0.76 ACP3 (0.50) ACP3P2RX7CNR2ALDH1A1POLB
SCHEMBL6564259 0.76 ACP3 (0.46) ACP3P2RX7CNR2ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5449831-A Process of preparing 2-methyl-3-aminobenzotrifluoride CENTRAL GLASS COMPANY, LIMITED (JP) 1995-09-12 US claimed
US-5600036-A 2-trifluoromethyl-4-chlorobenzalchloride and 2-methyl-3-nitro-5-chlorobenzotrifluoride useful as intermediates for preparing 2-methyl-3-aminobenzotrifluoride CENTRAL GLASS COMPANY, LIMITED (JP) 1997-02-04 US disclosed
US-5449831-A Process of preparing 2-methyl-3-aminobenzotrifluoride CENTRAL GLASS COMPANY, LIMITED (JP) 1995-09-12 US disclosed