Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328287 | 0.94 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAKDM4EACHEBACE1 | |
| SCHEMBL7326401 | 0.94 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAKDM4EACHEBACE1 | |
| SCHEMBL7326394 | 0.94 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAKDM4EACHEBACE1 | |
| Hydrochloric Acid SCHEMBL7326067 | 0.93 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAKDM4EACHEBACE1 | |
| Hydrochloric Acid SCHEMBL7324768 | 0.93 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAKDM4EACHEBACE1 | |
| Hydrochloric Acid SCHEMBL7331894 | 0.93 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAKDM4EACHEBACE1 | |
| Fumaric Acid SCHEMBL7330535 | 0.92 | ADRA1A (0.50) | SMN1; SMN2LMNAKDM4EACHEBACE1 | |
| Fumaric Acid SCHEMBL7331885 | 0.91 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAKMT2AMEN1ALDH1A1 | |
| Fumaric Acid SCHEMBL7325579 | 0.90 | GAA (0.55) | SMN1; SMN2KDM4EKMT2AMEN1ALDH1A1 | |
| Fumaric Acid SCHEMBL7335420 | 0.88 | KMT2A (0.43) | SMN1; SMN2LMNAKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |