Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.47 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GRN | P28799 | 1/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537395 | 0.98 | PTGS1 (0.65) | PTGS1CYP1A2KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL538151 | 0.84 | PTGS2 (0.51) | PTGS1PTGS2PDPK1CYP2C9 | |
| SCHEMBL7406011 | 0.84 | PTGS1 (0.49) | PTGS1PTGS2ALDH1A1KDM4ENR3C2 | |
| SCHEMBL7402120 | 0.83 | PTGS2 (0.65) | PTGS1CYP1A2PTGS2KDM4ENR3C2 | |
| SCHEMBL18865770 | 0.83 | PTGS2 (0.52) | PTGS1PTGS2PDPK1 | |
| SCHEMBL31420366 | 0.82 | PTGS2 (0.58) | PTGS1PTGS2KLKB1PDPK1MAPT | |
| SCHEMBL31522202 | 0.80 | TRPV1 (0.55) | — | |
| SCHEMBL537351 | 0.80 | PDPK1 (0.50) | PTGS1CYP1A2PTGS2ALDH1A1PDPK1 | |
| SCHEMBL537716 | 0.80 | PDPK1 (0.57) | PTGS1PTGS2PDPK1 | |
| SCHEMBL28012868 | 0.80 | PTGS1 (0.56) | PTGS1CYP1A2KCNJ6KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494925-A | TREATING DEGENERATIVE DISORDERS; PROTEOLYTIC ENZYME INHIBITOR | STERLING WINTHROP INC. (US) | 1996-02-27 | — | — | US | disclosed |