Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.60 |
| ▸ | DRD3 | P35462 | 8/20 | 0.60 |
| ▸ | DRD1 | P21728 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | THPO | P40225 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329629 | 1.00 | DRD2 (0.60) | DRD2DRD3DRD1CYP1A2CYP3A4 | |
| SCHEMBL7335610 | 0.91 | DRD2 (0.52) | DRD2DRD3DRD1CYP1A2CYP3A4 | |
| SCHEMBL7326407 | 0.91 | DRD2 (0.52) | DRD2DRD3DRD1CYP1A2CYP3A4 | |
| SCHEMBL7330393 | 0.89 | DRD2 (0.64) | DRD2DRD3DRD1DRD4 | |
| Hydrochloric Acid SCHEMBL7330903 | 0.88 | DRD2 (0.62) | DRD2DRD3DRD1DRD4 | |
| Hydrochloric Acid SCHEMBL7331395 | 0.88 | DRD2 (0.62) | DRD2DRD3DRD1DRD4 | |
| Hydrochloric Acid SCHEMBL7325770 | 0.88 | DRD2 (0.62) | DRD2DRD3DRD1DRD4 | |
| Hydrochloric Acid SCHEMBL7328457 | 0.88 | DRD2 (0.62) | DRD2DRD3DRD1DRD4 | |
| SCHEMBL7331426 | 0.86 | OPRM1 (0.47) | DRD2DRD3DRD1CYP1A2CYP3A4 | |
| SCHEMBL7338249 | 0.86 | OPRM1 (0.47) | DRD2DRD3DRD1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5196454-A | METHOD OF TREATING DISORDERS OF THE DOPAMINERGIC SYSTEMS USING 2,5-DIAMINOTETRALINES | BOEHRINGER INGELHEIM KG (DE) | 1993-03-23 | — | — | US | disclosed |
| EP-0402923-A2 | 2,5-Diaminotetralines, process for their preparation and their use as medicine | BOEHRINGER INGELHEIM KG (DE) | 1990-12-19 | — | — | EP | disclosed |