Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 9/20 | 0.60 |
| ▸ | TPSAB1 | Q15661 | 6/20 | 0.39 |
| ▸ | TPSD1 | Q9BZJ3 | 6/20 | 0.39 |
| ▸ | TPSG1 | Q9NRR2 | 6/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PAM | P19021 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL7329268 | 0.94 | ELANE (0.52) | ELANETPSAB1TPSD1TPSG1PRSS1 | |
| SCHEMBL7337549 | 0.89 | ELANE (0.58) | ELANEALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7329255 | 0.73 | ELANE (0.51) | ELANEALDH1A1 | |
| SCHEMBL11062218 | 0.62 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1KMT2APAM | |
| SCHEMBL14274359 | 0.61 | ALDH1A1 (0.59) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL31329613 | 0.60 | ALDH1A1 (0.56) | ELANEALDH1A1MAPK1L3MBTL1MEN1 | |
| SCHEMBL112999 | 0.59 | ALDH1A1 (0.68) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL1873977 | 0.59 | ALDH1A1 (0.68) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| Benzene SCHEMBL28160801 | 0.59 | ALDH1A1 (0.68) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL1332625 | 0.59 | ALDH1A1 (0.68) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5783589-A | 2-saccharinylmethyl aryl and arloxy acetates useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1998-07-21 | — | — | US | disclosed |
| US-5489604-A | TREATING DEGENERATIVE DISEASES | STERLING WINTHROP, INC. (US) | 1996-02-06 | — | — | US | disclosed |
| US-5385923-A | Treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-01-31 | — | — | US | disclosed |
| EP-0550112-A1 | 2-Saccharinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and pharmaceutical compositions contaning them | STERLING WINTHROP INC. (US) | 1993-07-07 | — | — | EP | disclosed |