Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TFPI | P10646 | 7/20 | 0.60 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.60 |
| ▸ | KDM1A | O60341 | 3/20 | 0.58 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.54 |
| ▸ | NMUR1 | Q9HB89 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | KDM5A | P29375 | 1/20 | 0.54 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.54 |
| ▸ | NPY1R | P25929 | 1/20 | 0.54 |
| ▸ | NPY2R | P49146 | 1/20 | 0.54 |
| ▸ | NPY4R | P50391 | 1/20 | 0.54 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.54 |
| ▸ | RAMP3 | O60896 | 3/20 | 0.54 |
| ▸ | CALCR | P30988 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7124762 | 0.91 | NMUR2 (0.52) | TFPIKDM1ANMUR2NMUR1NPY1R | |
| SCHEMBL30415437 | 0.88 | MAPK8 (0.59) | TFPIEPHA2KDM1ANMUR2NMUR1 | |
| SCHEMBL8441486 | 0.88 | KDM1A (0.54) | TFPIKDM1ANMUR2NMUR1NPY1R | |
| SCHEMBL29396082 | 0.87 | RAMP3 (0.64) | EPHA2KDM1ANMUR2NMUR1NPY1R | |
| SCHEMBL29404705 | 0.87 | RAMP3 (0.70) | TFPINMUR2NMUR1NPY1RNPY2R | |
| SCHEMBL26454697 | 0.86 | TFPI (0.63) | TFPIKDM1ANMUR2NMUR1NPY1R | |
| SCHEMBL26454508 | 0.86 | TFPI (0.63) | TFPIEPHA2KDM1ANMUR2NMUR1 | |
| SCHEMBL30262164 | 0.85 | EPHA2 (0.62) | TFPIEPHA2KDM1AMAOBKDM5A | |
| SCHEMBL30640886 | 0.85 | RAMP3 (0.63) | EPHA2KDM1ANMUR2NMUR1MAOB | |
| SCHEMBL9807268 | 0.85 | KDM1A (0.57) | TFPIEPHA2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5438118-A | Peptide mimics having constrained peptide backbone | SMITHKLINE BEECHMAN CORP. (US) | 1995-08-01 | — | — | US | disclosed |
| EP-0594586-A4 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 1994-08-17 | — | — | EP | disclosed |
| EP-0575500-A4 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 1994-06-01 | — | — | EP | disclosed |
| EP-0594586-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0559793-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0538366-A4 | — | — | 1994-04-20 | — | — | EP | disclosed |
| EP-0538396-A4 | — | — | 1994-04-13 | — | — | EP | disclosed |
| EP-0538383-A4 | — | — | 1994-04-13 | — | — | EP | disclosed |
| EP-0575500-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-12-29 | — | — | EP | disclosed |
| EP-0559793-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-15 | — | — | EP | disclosed |
| EP-0538383-A1 | INHIBITORS OF ASPARTIC PROTEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1993002674-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-18 | — | — | WO | disclosed |
| WO-1992015319-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-09-17 | — | — | WO | disclosed |
| WO-1992009297-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-11 | — | — | WO | disclosed |
| WO-1992000750-A1 | RETROVIRAL PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |
| WO-1992000956-A1 | INHIBITORS OF ASPARTIC PROTEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |
| WO-1992000954-A1 | ASPARTIC PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |
| WO-1992000948-A1 | INHIBITORS OF RETROVIRAL PROTEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |
| WO-1991010442-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-25 | — | — | WO | disclosed |
| EP-0352000-A2 | Retroviral protease binding peptides | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-24 | — | — | EP | disclosed |