Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | AGXT | P21549 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24242154 | 0.91 | IAPP (0.57) | TAAR1FFAR1FFAR4ESR1NR3C1 | |
| SCHEMBL28210558 | 0.88 | FFAR1 (0.57) | TAAR1FFAR1FFAR4ESR1NR3C1 | |
| SCHEMBL6586 | 0.86 | FFAR1 (0.68) | TAAR1FFAR1FFAR4ESR1NR3C1 | |
| SCHEMBL24242075 | 0.85 | FFAR1 (0.48) | TAAR1FFAR1FFAR4ESR1NR3C1 | |
| SCHEMBL4234560 | 0.85 | ALDH1A1 (0.60) | TAAR1FFAR1FFAR4ESR1NR3C1 | |
| SCHEMBL2754670 | 0.85 | TAAR1 (0.58) | TAAR1FFAR1FFAR4ESR1NR3C1 | |
| SCHEMBL3962652 | 0.85 | TAAR1 (0.53) | TAAR1FFAR1FFAR4ESR1NR3C1 | |
| SCHEMBL5666545 | 0.85 | TAAR1 (0.53) | TAAR1FFAR1FFAR4ESR1NR3C1 | |
| SCHEMBL9479297 | 0.83 | HDAC6 (0.65) | TAAR1FFAR1FFAR4MEN1ALDH1A1 | |
| SCHEMBL23395779 | 0.82 | NPC1 (0.51) | TAAR1FFAR1FFAR4ESR1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104418801-B | Benzo piperidine ring and benzo morpholine cyclics, its preparation method and medical applications | 上海润诺生物科技有限公司 | 2016-10-05 | — | — | CN | disclosed |
| CN-104418801-A | Benzopiperidine-ring and benzomorpholine-ring compound, preparation method and medical application thereof | SHANGHAI RUNNUO BIOTECHNOLOGY CO LTD | 2015-03-18 | — | — | CN | disclosed |
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |