Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.73 |
| ▸ | BCHE | P06276 | 5/20 | 0.63 |
| ▸ | HTR6 | P50406 | 8/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12765737 | 0.91 | SLC6A4 (0.81) | SLC6A4BCHEHTR6LMNAHTT | |
| SCHEMBL18426580 | 0.85 | SLC6A4 (0.76) | SLC6A4BCHELMNAHTTKMT2A | |
| SCHEMBL30592374 | 0.85 | SLC6A4 (1.00) | SLC6A4HTR6KMT2AMAPTMEN1 | |
| SCHEMBL1998835 | 0.85 | SLC6A4 (1.00) | SLC6A4HTR6KMT2AMAPTMEN1 | |
| SCHEMBL31302691 | 0.83 | SLC6A4 (0.68) | SLC6A4BCHEHTR6LMNAHTT | |
| SCHEMBL31302667 | 0.83 | SLC6A4 (0.68) | SLC6A4BCHEHTR6LMNAHTT | |
| SCHEMBL4822564 | 0.81 | SLC6A4 (0.71) | SLC6A4BCHEHTR6KMT2AMAPT | |
| SCHEMBL8790419 | 0.80 | HTR6 (0.91) | SLC6A4HTR6LMNAHTTKMT2A | |
| SCHEMBL11471892 | 0.79 | BCHE (0.79) | BCHELMNAHTTKMT2AMAPT | |
| Ethoxycarbonyl Group SCHEMBL27597886 | 0.79 | SLC6A4 (0.56) | SLC6A4BCHEHTR6LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104177283-B | The method preparing bisindole methane derivative in the presence of amine salt | 陕西师范大学 | 2016-08-17 | — | — | CN | disclosed |
| CN-104177283-A | Method for preparing bis (indolyl) methane derivative in presence of amine salt | UNIV SHAANXI NORMAL | 2014-12-03 | — | — | CN | disclosed |
| CN-103467354-A | Method for preparing diindolyl methane derivatives | UNIV SHAANXI NORMAL | 2013-12-25 | — | — | CN | disclosed |
| EP-2044016-B1 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | GRUENENTHAL GMBH (DE) | 2012-12-05 | — | — | EP | disclosed |
| US-8138187-B2 | Substituted heteroaryl derivatives | GRUENENTHAL GMBH (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| EP-2044016-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009415-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1- AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2008-01-24 | — | — | WO | disclosed |
| CN-100351234-C | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA TAU IND FARMACEUTI (IT) | 2007-11-28 | — | — | CN | disclosed |
| CN-1733722-A | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA TAU IND FARMACEUTI (IT) | 2006-02-15 | — | — | CN | disclosed |
| CN-1232518-C | Bis-heterocyclic compounds with antitumor and chemosensitive activity | SIGMA TAU IND FARMACEUTI (IT) | 2005-12-21 | — | — | CN | disclosed |
| CN-1473150-A | Bis-heterocyclic compounds with antitumor and chemosensitive activity | ϣ��������ҩ��ҵ��˾ | 2004-02-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | SLC6A4 1150/4885BCHE 2886/4885HTR6 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.