Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433532 | 0.81 | JAK2 (0.48) | NPC1RAB9AHSD11B1 | |
| SCHEMBL20237058 | 0.71 | NPC1 (0.48) | NPC1RAB9AHSD11B1MMP1MMP3 | |
| SCHEMBL18484113 | 0.67 | HSD11B1 (0.45) | NPC1RAB9AHSD11B1MEN1KMT2A | |
| SCHEMBL2045062 | 0.66 | NPC1 (0.59) | NPC1RAB9AHSD11B1CYP3A4CYP2C9 | |
| SCHEMBL2045918 | 0.66 | NPC1 (0.59) | NPC1RAB9AHSD11B1 | |
| SCHEMBL16601272 | 0.65 | SMN1; SMN2 (0.56) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL20548406 | 0.65 | SMN1; SMN2 (0.56) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL16199651 | 0.65 | SMN1; SMN2 (0.56) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL16608211 | 0.65 | SMN1; SMN2 (0.56) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL1249749 | 0.65 | NPC1 (0.42) | NPC1RAB9AMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627190-A | TREATMENT OF ANXIETY, PSYCHOSES, DEPRESSION, ORGASTROINTESTINAL DISORDERS, 5-HYDROXYTRYPTAMINE ANTAGONISTS | G. D. SEARLE & CO. (US) | 1997-05-06 | — | — | US | disclosed |
| US-5612366-A | USEFUL IN TREATMENT OF CENTRAL NERVOUS SYSTEM AND GASTROINTESTINAL MOTILITY DISORDERS | G. D. SEARLE & CO. (US) | 1997-03-18 | — | — | US | disclosed |
| US-5516782-A | FOR TREATMENT OF ANXIETY, PSYCHOSES, DEPRESSION OR GASTROINTESTINAL MOTILITY DISTURBANCES | G. D. SEARLE & CO. (US) | 1996-05-14 | — | — | US | disclosed |
| US-5430040-A | Anxiolytic agents, antidepressants, antiserotonine agents; treatment of psychosis, gastrointestinal disorders | G. D. SEARLE & CO. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5318977-A | New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents | G. D. SEARLE & CO. (US) | 1994-06-07 | — | — | US | disclosed |
| US-5280029-A | Containing imidazolo(1,5-a)pyridine | G. D. SEARLE & CO. (US) | 1994-01-18 | — | — | US | disclosed |
| US-5234921-A | Antagonists of the serotonin 5-HT3 receptor; gastrointestinal disorders; antidepressants; drug abuse | G. D. SEARLE & CO. (US) | 1993-08-10 | — | — | US | disclosed |
| US-5227377-A | Serotonin 5-HT3 receptor antagonists | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | disclosed |
| US-5219850-A | Anyiolytic agents, gastrointestinal disorders, antiserotonin agents | G. D. SEARLE & CO. (US) | 1993-06-15 | — | — | US | disclosed |
| US-5196547-A | Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof | G. D. SEARLE & CO. (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0504680-A1 | New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents | G.D. Searle & Co. (US) | 1992-09-23 | — | — | EP | disclosed |
| WO-1992015590-A1 | NEW MESO-AZACYCLIC AROMATIC ACID AMIDES AND ESTERS AS NOVEL SEROTONERGIC AGENTS | G.D. SEARLE & CO. (US) | 1992-09-17 | — | — | WO | disclosed |
| US-5137893-A | Anxilytic agents; antidepressants; antiemetics | G. D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |