Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 3/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18484113 | 0.85 | HSD11B1 (0.45) | JAK2JAK1HSD11B1GPR119STS | |
| SCHEMBL31288410 | 0.81 | JAK2 (0.53) | JAK2JAK1GPR119NR1H2STS | |
| SCHEMBL30993456 | 0.81 | JAK2 (0.53) | JAK2JAK1GPR119NR1H2STS | |
| SCHEMBL6095209 | 0.81 | JAK2 (0.53) | JAK2JAK1GPR119NR1H2STS | |
| SCHEMBL27534101 | 0.81 | ESR2 (0.47) | JAK2JAK1HSD11B1GPR119NR1H2 | |
| SCHEMBL7333103 | 0.81 | NPC1 (0.42) | HSD11B1NPC1RAB9A | |
| SCHEMBL2817602 | 0.79 | ESR2 (0.43) | JAK2JAK1HSD11B1GPR119NR1H2 | |
| SCHEMBL994232 | 0.79 | ESR2 (0.43) | JAK2JAK1HSD11B1GPR119NR1H2 | |
| SCHEMBL18986945 | 0.78 | JAK2 (0.53) | JAK2JAK1HSD11B1GPR119NR1H2 | |
| SCHEMBL16836282 | 0.77 | JAK2 (0.45) | JAK2JAK1GPR119STSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627190-A | TREATMENT OF ANXIETY, PSYCHOSES, DEPRESSION, ORGASTROINTESTINAL DISORDERS, 5-HYDROXYTRYPTAMINE ANTAGONISTS | G. D. SEARLE & CO. (US) | 1997-05-06 | — | — | US | disclosed |
| US-5612366-A | USEFUL IN TREATMENT OF CENTRAL NERVOUS SYSTEM AND GASTROINTESTINAL MOTILITY DISORDERS | G. D. SEARLE & CO. (US) | 1997-03-18 | — | — | US | disclosed |
| US-5534521-A | SEROTONIN ANTAGONISTS | G. D. SEARLE & CO. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5521193-A | SEROTONIN AGONISTS AND ANTAGONISTS | G. D. SEARLE & CO. (US) | 1996-05-28 | — | — | US | disclosed |
| US-5516782-A | FOR TREATMENT OF ANXIETY, PSYCHOSES, DEPRESSION OR GASTROINTESTINAL MOTILITY DISTURBANCES | G. D. SEARLE & CO. (US) | 1996-05-14 | — | — | US | disclosed |
| US-5430040-A | Anxiolytic agents, antidepressants, antiserotonine agents; treatment of psychosis, gastrointestinal disorders | G. D. SEARLE & CO. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5318977-A | New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents | G. D. SEARLE & CO. (US) | 1994-06-07 | — | — | US | disclosed |
| US-5280029-A | Containing imidazolo(1,5-a)pyridine | G. D. SEARLE & CO. (US) | 1994-01-18 | — | — | US | disclosed |
| US-5227377-A | Serotonin 5-HT3 receptor antagonists | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | disclosed |
| US-5219850-A | Anyiolytic agents, gastrointestinal disorders, antiserotonin agents | G. D. SEARLE & CO. (US) | 1993-06-15 | — | — | US | disclosed |
| EP-0528026-A1 | NEW MESO-AZACYCLIC AROMATIC ACID AMIDES AND ESTERS AS NOVEL SEROTONERGIC AGENTS | G.D. SEARLE & CO. (US) | 1993-02-24 | — | — | EP | disclosed |
| EP-0504680-A1 | New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents | G.D. Searle & Co. (US) | 1992-09-23 | — | — | EP | disclosed |