Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324595 | 0.84 | CYP1A2 (0.53) | TSHRHTTCYP1A2CPB2 | |
| SCHEMBL7324591 | 0.84 | CYP1A2 (0.53) | TSHRHTTCYP1A2CPB2 | |
| SCHEMBL7324586 | 0.84 | CYP1A2 (0.53) | TSHRHTTCYP1A2CPB2 | |
| SCHEMBL7332824 | 0.79 | PPARG (0.52) | PPARGEPHX2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7141356 | 0.78 | EPHX2 (0.51) | PPARGEPHX2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7436917 | 0.78 | PPARG (0.51) | PPARGEPHX2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10521821 | 0.77 | MMP8 (0.61) | PPARGEPHX2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1127424 | 0.77 | MEN1 (0.57) | PKMPPARGEPHX2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7420885 | 0.77 | EPHX2 (0.50) | PPARGEPHX2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7366876 | 0.76 | MMP1 (0.51) | PPARGEPHX2SMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4914129-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1990-04-03 | — | — | US | disclosed |
| US-4889869-A | ANTIALDOSTERONISM AGENTS | CIBA-GEIGY CORPORATION (US) | 1989-12-26 | — | — | US | disclosed |
| US-4758584-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1988-07-19 | — | — | US | disclosed |