Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 12/20 | 0.57 |
| ▸ | EDNRB | P24530 | 8/20 | 0.57 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331707 | 0.91 | EDNRA (0.48) | EDNRAEDNRBAGTR1CYP3A4 | |
| SCHEMBL9127085 | 0.86 | EDNRB (0.51) | EDNRAEDNRBPPARGPPARA | |
| SCHEMBL7336115 | 0.85 | EDNRA (0.61) | EDNRAEDNRBAGTR1PDE5ACYP3A4 | |
| SCHEMBL7339520 | 0.84 | EDNRA (0.60) | EDNRAEDNRBAGTR1PDE5APPARG | |
| SCHEMBL7333290 | 0.84 | EDNRA (0.71) | EDNRAEDNRBAGTR1 | |
| SCHEMBL7338441 | 0.81 | EDNRA (0.60) | EDNRAEDNRBAGTR1PPARGPPARA | |
| SCHEMBL8904044 | 0.80 | EDNRA (0.55) | EDNRAEDNRBAGTR1PPARGPPARA | |
| SCHEMBL7329159 | 0.79 | EDNRA (0.53) | EDNRAEDNRBPPARGPPARA | |
| SCHEMBL9129724 | 0.78 | PPARG (0.44) | EDNRAEDNRBPPARGPPARA | |
| SCHEMBL9307920 | 0.78 | EDNRB (0.44) | EDNRAEDNRBPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0617001-B1 | Phenoxyphenylacetic acid derivatives | MERCK & CO INC (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5767310-A | Phenoxyphenylacetic acid derivatives | MERCK & CO., INC. (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0774965-A4 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO INC (US) | 1997-10-29 | — | — | EP | disclosed |
| US-5668176-A | ENDOTHELIN ANTAGONIST | MERCK & CO. INC. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0774965-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO. INC. (US) | 1997-05-28 | — | — | EP | disclosed |
| US-5565485-A | TREATING CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1996009818-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| WO-1996004905-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1996-02-22 | — | — | WO | disclosed |
| WO-1994021590-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1994-09-29 | — | — | WO | disclosed |
| EP-0617001-A1 | Phenoxyphenylacetic acid derivatives | MERCK & CO. INC. (US) | 1994-09-28 | — | — | EP | disclosed |