Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.60 |
| ▸ | EDNRB | P24530 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 8/20 | 0.43 |
| ▸ | PPARA | Q07869 | 8/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339368 | 0.90 | EDNRA (0.61) | EDNRAEDNRBALDH1A1MAPTTSHR | |
| SCHEMBL7339477 | 0.90 | EDNRA (0.59) | EDNRAEDNRBALDH1A1MAPTTSHR | |
| SCHEMBL8903642 | 0.89 | EDNRA (0.60) | EDNRAEDNRBALDH1A1MAPTTSHR | |
| SCHEMBL7336115 | 0.88 | EDNRA (0.61) | EDNRAEDNRBMAPK9PPARGPPARA | |
| SCHEMBL7339520 | 0.87 | EDNRA (0.60) | EDNRAEDNRBPPARGPPARAAGTR1 | |
| SCHEMBL8904044 | 0.86 | EDNRA (0.55) | EDNRAEDNRBMAPK9PPARGPPARA | |
| SCHEMBL7329159 | 0.85 | EDNRA (0.53) | EDNRAEDNRBALDH1A1MAPTMAPK9 | |
| SCHEMBL8789081 | 0.84 | EDNRA (0.67) | EDNRAEDNRBALDH1A1MAPK9AGTR1 | |
| SCHEMBL7336213 | 0.82 | EDNRA (0.57) | EDNRAEDNRBMAPTTSHRAGTR1 | |
| SCHEMBL7331390 | 0.82 | PPARG (0.56) | EDNRAEDNRBPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996009818-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | claimed |
| US-5767310-A | Phenoxyphenylacetic acid derivatives | MERCK & CO., INC. (US) | 1998-06-16 | — | — | US | disclosed |
| US-5668176-A | ENDOTHELIN ANTAGONIST | MERCK & CO. INC. (US) | 1997-09-16 | — | — | US | disclosed |
| US-5565485-A | TREATING CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1996009818-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| WO-1996004905-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1996-02-22 | — | — | WO | disclosed |
| WO-1994021590-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1994-09-29 | — | — | WO | disclosed |
| EP-0617001-A1 | Phenoxyphenylacetic acid derivatives | MERCK & CO. INC. (US) | 1994-09-28 | — | — | EP | disclosed |