Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13059438 | 0.86 | KMT2A (0.68) | KMT2ANPC1MAPTNPSR1HPGD | |
| SCHEMBL28263863 | 0.85 | KMT2A (0.63) | KMT2ANPC1MAPTNPSR1HPGD | |
| SCHEMBL14996180 | 0.83 | KMT2A (0.67) | KMT2ANPC1MAPTNPSR1ALDH1A1 | |
| SCHEMBL26544897 | 0.83 | KMT2A (0.61) | KMT2ANPC1MAPTNPSR1HPGD | |
| SCHEMBL22196923 | 0.82 | KMT2A (0.66) | KMT2ANPC1MAPTNPSR1HPGD | |
| SCHEMBL21255890 | 0.82 | KMT2A (0.66) | KMT2ANPC1MAPTNPSR1ALDH1A1 | |
| SCHEMBL3149402 | 0.82 | ALDH1A1 (0.57) | KMT2ANPC1MAPTNPSR1HPGD | |
| SCHEMBL2873071 | 0.81 | MAPK1 (0.65) | KMT2ANPC1MAPTNPSR1ALDH1A1 | |
| SCHEMBL9195698 | 0.80 | MAPT (0.58) | KMT2ANPC1MAPTNPSR1HPGD | |
| SCHEMBL6985977 | 0.80 | KMT2A (0.63) | KMT2ANPC1MAPTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781126-B1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON SPA (IT) | 2001-12-12 | — | — | EP | disclosed |
| US-5674909-A | FOR TREATMENT OF CARDIOVASCULAR DISORDERS | ZAMBON GROUP (IT) | 1997-10-07 | — | — | US | disclosed |
| EP-0781126-A2 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008228-A2 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.P.A. (IT) | 1996-03-21 | — | — | WO | disclosed |