Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10756718 | 1.00 | REN (0.53) | RENMMP2MMP9MMP8TSHR | |
| SCHEMBL10422508 | 0.92 | REN (0.52) | RENMMP2MMP9MMP8 | |
| Water SCHEMBL10422512 | 0.91 | REN (0.52) | RENMMP2MMP9MMP8 | |
| SCHEMBL10874442 | 0.90 | REN (0.52) | RENMMP2MMP9MMP8 | |
| SCHEMBL7336372 | 0.90 | REN (0.52) | RENMMP2MMP9MMP8 | |
| SCHEMBL10420799 | 0.89 | REN (0.55) | REN | |
| SCHEMBL10421161 | 0.88 | REN (0.49) | RENMMP2MMP9MMP8 | |
| SCHEMBL10421591 | 0.86 | REN (0.56) | REN | |
| SCHEMBL10422015 | 0.86 | REN (0.58) | RENMMP2MMP9MMP8PSMB8 | |
| SCHEMBL7283916 | 0.86 | REN (0.48) | RENMMP2MMP9MMP8TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0396065-A1 | Novel amino acid derivatives possessing renin-inhibitory activities | Japan Tobacco Inc. (JP) | 1990-11-07 | — | — | EP | disclosed |
| US-4870183-A | RENIN INHIBITORS, HYPOTENSIVES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0252727-A1 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-01-13 | — | — | EP | disclosed |
| US-4711958-A | HYPOTENSIVE AGENTS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1987-12-08 | — | — | US | disclosed |
| EP-0244083-A2 | Amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |
| US-4656269-A | RENIN INHIBITORY EFFECT WHEN ADMINISTERING ORALLY; HYPOTENSIVE AGENTS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1987-04-07 | — | — | US | disclosed |
| EP-0200406-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-11-05 | — | — | EP | disclosed |