Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 4/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL10422512 | 0.99 | REN (0.52) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10421161 | 0.96 | REN (0.49) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL7336372 | 0.93 | REN (0.52) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10874442 | 0.93 | REN (0.52) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL7333736 | 0.92 | REN (0.53) | RENMMP2MMP9MMP8 | |
| SCHEMBL10756718 | 0.92 | REN (0.53) | RENMMP2MMP9MMP8 | |
| SCHEMBL7283916 | 0.89 | REN (0.48) | RENMMP2MMP9MMP8 | |
| SCHEMBL7283907 | 0.89 | REN (0.48) | RENMMP2MMP9MMP8 | |
| SCHEMBL10748105 | 0.89 | REN (0.43) | RENHRH4MMP2MMP9MMP8 | |
| SCHEMBL10749770 | 0.88 | REN (0.44) | RENHRH4MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904660-A | HYPOTENSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-02-27 | — | — | US | disclosed |
| US-4711958-A | HYPOTENSIVE AGENTS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1987-12-08 | — | — | US | disclosed |
| EP-0244083-A2 | Amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |