⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733419 | 0.87 | — | — | |
| SCHEMBL735342 | 0.84 | RNMT (0.31) | — | |
| SCHEMBL733412 | 0.80 | RNMT (0.30) | — | |
| SCHEMBL754765 | 0.78 | RNMT (0.32) | — | |
| SCHEMBL735249 | 0.75 | PRMT5 (0.34) | — | |
| SCHEMBL733591 | 0.70 | P2RY6 (0.34) | — | |
| SCHEMBL753363 | 0.69 | POLB (0.34) | — | |
| SCHEMBL733418 | 0.69 | POLB (0.32) | — | |
| SCHEMBL733920 | 0.68 | KDM4E (0.39) | — | |
| SCHEMBL9539565 | 0.68 | TYMP (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138330-B2 | Solid phase synthesis via deblocking immobilized nucleoside, then coupling acyl protected nucleoside phosphoramidite | SIGMA-ALDRICH CO. LLC (US) | 2012-03-20 | — | — | US | disclosed |