Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7071566 | 0.92 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1HTTMAPK1MCHR1 | |
| SCHEMBL7825784 | 0.86 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1HTTMAPK1MCHR1 | |
| SCHEMBL7069387 | 0.84 | EDNRA (0.51) | ALDH1A1L3MBTL1HTTMCHR1HCRTR2 | |
| SCHEMBL7069879 | 0.84 | EDNRA (0.47) | ALDH1A1L3MBTL1HTTMAPK1KDM4E | |
| SCHEMBL7337708 | 0.83 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1MAPTHTTMAPK1 | |
| SCHEMBL7067319 | 0.80 | EDNRB (0.55) | ALDH1A1L3MBTL1MAPTHTTMAPK1 | |
| SCHEMBL7067202 | 0.79 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1MAPTHTTMAPK1 | |
| SCHEMBL7069884 | 0.79 | GAA (0.48) | ALDH1A1L3MBTL1MAPTHTTMCHR1 | |
| SCHEMBL7340169 | 0.79 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1MAPTHTTMAPK1 | |
| SCHEMBL7065442 | 0.79 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1MAPTHTTMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |