Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336002 | 0.90 | SMN1; SMN2 (0.47) | ALDH1A1L3MBTL1HTTSMN1; SMN2TSHR | |
| SCHEMBL7829254 | 0.88 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1HTTSMN1; SMN2TSHR | |
| SCHEMBL7340947 | 0.88 | LMNA (0.46) | ALDH1A1L3MBTL1HTTSMN1; SMN2TSHR | |
| SCHEMBL7342596 | 0.87 | HCRTR2 (0.47) | ALDH1A1HTTSMN1; SMN2TSHRPKM | |
| SCHEMBL7337656 | 0.86 | LMNA (0.44) | ALDH1A1L3MBTL1KMT2ALMNAMAPT | |
| SCHEMBL7337057 | 0.85 | POLB (0.44) | ALDH1A1L3MBTL1HTTPOLBHSD11B1 | |
| SCHEMBL7340169 | 0.85 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1HTTSMN1; SMN2TSHR | |
| SCHEMBL7334174 | 0.83 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1HTTSMN1; SMN2KMT2A | |
| SCHEMBL7334097 | 0.83 | HSD11B1 (0.49) | ALDH1A1L3MBTL1HTTSMN1; SMN2TSHR | |
| SCHEMBL7343851 | 0.82 | MAPT (0.60) | MAPTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-0811001-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |