Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 4/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CBX7 | O95931 | 2/20 | 0.36 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.36 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.36 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734639 | 0.78 | IDO1 (0.47) | ALDH1A1MAPTALOX12ADCY8GHSR | |
| SCHEMBL10250086 | 0.69 | KMT2A (0.40) | ALDH1A1MAPTALOX12 | |
| SCHEMBL699106 | 0.68 | IDO1 (0.48) | ALDH1A1MAPTIDO1CBX7CDYL | |
| SCHEMBL8361234 | 0.68 | AKR1B1 (0.38) | MAPK1ABCB1 | |
| SCHEMBL8361432 | 0.63 | KMT2A (0.33) | MAPT | |
| SCHEMBL128252 | 0.63 | HTR6 (0.51) | ALDH1A1TP53MAPTGHSRHTR6 | |
| SCHEMBL10249878 | 0.62 | KMT2A (0.41) | ALDH1A1MAPK1 | |
| SCHEMBL9704171 | 0.62 | MAPK1 (0.40) | MAPK1 | |
| SCHEMBL10249887 | 0.62 | KMT2A (0.39) | ALDH1A1MAPT | |
| SCHEMBL7607750 | 0.61 | SMN1; SMN2 (0.48) | ALDH1A1MAPTADCY8IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138187-B2 | Substituted heteroaryl derivatives | GRUENENTHAL GMBH (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | ALDH1A1 3171/4885TP53 3011/4885MAPT 3593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.