Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6795739 | 0.85 | HSD11B1 (0.49) | HSD11B1MAPTPOLBTP53SMN1; SMN2 | |
| SCHEMBL7342790 | 0.84 | HSD11B1 (0.58) | HSD11B1MAPTPOLB | |
| SCHEMBL6541814 | 0.83 | HSD11B1 (0.52) | HSD11B1MAPTPOLBTP53CYP3A4 | |
| SCHEMBL6541132 | 0.83 | HSD11B1 (0.50) | HSD11B1MAPTPOLBTP53SMN1; SMN2 | |
| SCHEMBL7343733 | 0.83 | HSD11B1 (0.57) | HSD11B1MAPTPOLBTP53ALDH1A1 | |
| SCHEMBL7831589 | 0.83 | HSD11B1 (0.49) | HSD11B1MAPTPOLBTP53SMN1; SMN2 | |
| SCHEMBL6542210 | 0.82 | HSD11B1 (0.49) | HSD11B1MAPTPOLBTP53ALDH1A1 | |
| SCHEMBL6542067 | 0.82 | HSD11B1 (0.49) | HSD11B1MAPTPOLBTP53SMN1; SMN2 | |
| SCHEMBL6542769 | 0.82 | HSD11B1 (0.49) | HSD11B1MAPTPOLBTP53SMN1; SMN2 | |
| SCHEMBL6542054 | 0.82 | HSD11B1 (0.52) | HSD11B1MAPTPOLBTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | claimed |
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |