Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 10/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342790 | 0.87 | HSD11B1 (0.58) | HSD11B1MAPTPOLB | |
| SCHEMBL7825737 | 0.85 | HSD11B1 (0.52) | HSD11B1MAPTTP53POLBKDM4E | |
| SCHEMBL7334969 | 0.83 | HSD11B1 (0.55) | HSD11B1MAPTTP53POLBALDH1A1 | |
| SCHEMBL7335046 | 0.82 | HSD11B1 (0.56) | HSD11B1MAPTTP53POLB | |
| SCHEMBL7339659 | 0.82 | HSD11B1 (0.54) | HSD11B1MAPTTP53POLB | |
| SCHEMBL7335669 | 0.82 | HSD11B1 (0.54) | HSD11B1MAPTTP53POLBALDH1A1 | |
| SCHEMBL7336853 | 0.82 | HSD11B1 (0.55) | HSD11B1MAPTTP53POLBHSD17B10 | |
| SCHEMBL7336087 | 0.80 | HSD11B1 (0.52) | HSD11B1MAPTTP53POLBMEN1 | |
| SCHEMBL6542054 | 0.79 | HSD11B1 (0.52) | HSD11B1MAPTTP53POLBALDH1A1 | |
| SCHEMBL6541814 | 0.78 | HSD11B1 (0.52) | HSD11B1MAPTTP53POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | claimed |
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |