Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19814664 | 0.83 | CNR2 (0.38) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL2507068 | 0.79 | HPGD (0.36) | HPGDALDH1A1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL697727 | 0.75 | TP53 (0.42) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL734691 | 0.74 | CNR2 (0.40) | HPGDALDH1A1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL734040 | 0.73 | CNR2 (0.39) | HPGDSMN1; SMN2NOS1CNR2 | |
| SCHEMBL23972752 | 0.73 | SMN1; SMN2 (0.38) | KMT2ASMN1; SMN2NPC1RAB9ANOS1 | |
| SCHEMBL735313 | 0.72 | ALDH1A1 (0.33) | HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL696381 | 0.69 | MEN1 (0.43) | KMT2AMEN1 | |
| SCHEMBL736352 | 0.69 | L3MBTL1 (0.31) | HPGD | |
| SCHEMBL23320022 | 0.68 | SMN1; SMN2 (0.38) | KMT2ASMN1; SMN2NPC1RAB9ANOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138187-B2 | Substituted heteroaryl derivatives | GRUENENTHAL GMBH (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | HPGD 1007/4885ALDH1A1 3171/4885KMT2A 2453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.