Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11514098 | 0.98 | HTR3A (0.43) | HTR3ANOTUMPARP1AKR1C4AKR1C3 | |
| SCHEMBL7324153 | 0.95 | HTR3A (0.43) | HTR3ANOTUMPARP1AKR1C4AKR1C3 | |
| SCHEMBL4387990 | 0.90 | HTR3A (0.51) | HTR3APARP1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL30094449 | 0.90 | HTR3A (0.51) | HTR3APARP1AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL9868892 | 0.87 | HTR3A (0.43) | HTR3ANOTUMPARP1 | |
| SCHEMBL8366432 | 0.82 | HTR3A (0.43) | HTR3APARP1KDM4EALDH1A1 | |
| SCHEMBL8481275 | 0.81 | PARP1 (0.62) | NOTUMPARP1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL7395597 | 0.81 | PARP1 (0.40) | NOTUMPARP1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL9867616 | 0.81 | PARP1 (0.40) | NOTUMPARP1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL9868204 | 0.79 | PARP1 (0.36) | NOTUMPARP1KDM4EHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1077891-C | 5-phenyl-3- (piperidin-4-yl) -1,3, 4-oxadiazol-2 (3H) -one derivatives useful as 5-HT4 or H3 receptor ligands | SYNTHELABO (FR) | 2002-01-16 | — | — | CN | disclosed |
| US-6127379-A | TREATING IRRITABLE BOWEL SYNDROME, URINARY INCONTINENCE, ATRIAL ARRHYTHMIA OR STROKE | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-10-03 | — | — | US | disclosed |
| US-5929089-A | ANTISEROTONINE AGENT | SYNTHELABO (FR) | 1999-07-27 | — | — | US | disclosed |
| EP-0863897-B1 | 5-PHENYL-3-(PIPERIDIN-4-YL)-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES FOR USE AS 5-HT4- OR H3-RECEPTOR LIGANDS | SYNTHELABO (FR) | 1999-06-16 | — | — | EP | disclosed |
| CN-1202169-A | 5-phenyl-3- (piperidin-4-yl) -1, 3, 4-oxadiazol-2 (3H) -one derivatives useful as 5-HT 4 or H3 receptor ligands | SYNTHELABO (FR) | 1998-12-16 | — | — | CN | disclosed |
| US-5502209-A | SIDE EFFECT REDUCTION, GASTROINTESTINAL | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-03-26 | — | — | US | disclosed |
| EP-0691341-A1 | Benzopyrancarboxamide derivatives, salt thereof, process for the preparation of same and use thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-01-10 | — | — | EP | disclosed |
| EP-0684947-A1 | AMIDE COMPOUNDS WITH PHARMACOLOGICAL ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-12-06 | — | — | EP | disclosed |
| EP-0625149-A1 | BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-11-23 | — | — | EP | disclosed |
| WO-1994019344-A1 | AMIDE COMPOUNDS WITH PHARMACOLOGICAL ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1994-09-01 | — | — | WO | disclosed |
| WO-1993016072-A1 | BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-19 | — | — | WO | disclosed |
| US-5006570-A | Dihydrobenzofuran- and chroman-carboxamide derivatives, processes for the preparation thereof and use thereof as neuroleptics | LABORATOIRES DELAGRANGE (FR) | 1991-04-09 | — | — | US | disclosed |
| US-4278680-A | Hypoglycaemically and hypolipidaemically active derivatives of phenylacetic acid | BOEHRINGER MANNHEIM GMBH (DE) | 1981-07-14 | — | — | US | disclosed |
| US-4207341-A | Hypoglycaemically and hypolipidaemically active derivatives of phenylacetic acid | BOEHRINGER-MANNHEIM GMBH (DE) | 1980-06-10 | — | — | US | disclosed |