Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 3/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 6/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329936 | 0.97 | AVPR1A (0.40) | AVPR1AAVPR1BCHRM1HSD17B10TSHR | |
| SCHEMBL7332734 | 0.88 | REN (0.42) | RENMEN1ALDH1A1KMT2A | |
| SCHEMBL7338004 | 0.88 | KMT2A (0.39) | AVPR1ATSHRRENF2KMT2A | |
| SCHEMBL7330563 | 0.87 | AVPR1A (0.36) | AVPR1AAVPR1BCHRM1HSD17B10TSHR | |
| SCHEMBL7338775 | 0.85 | CAPN1 (0.34) | AVPR1ATSHRRENF2MEN1 | |
| SCHEMBL7330525 | 0.85 | REN (0.38) | AVPR1AAVPR1BCHRM1HSD17B10TSHR | |
| SCHEMBL7330557 | 0.83 | AVPR1A (0.38) | AVPR1AAVPR1BCHRM1HSD17B10TSHR | |
| SCHEMBL7335615 | 0.83 | F2 (0.34) | AVPR1ATSHRRENF2MEN1 | |
| SCHEMBL7337567 | 0.81 | REN (0.38) | AVPR1ACHRM1HSD17B10TSHRREN | |
| SCHEMBL9437478 | 0.81 | KMT2A (0.41) | AVPR1ARENMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |