Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330525 | 0.97 | REN (0.38) | RENCTSSHSD17B10CHRM1AVPR1A | |
| SCHEMBL7338773 | 0.90 | LMNA (0.38) | RENCTSSTSHRGAACYP2C19 | |
| SCHEMBL7337794 | 0.90 | KMT2A (0.43) | RENCTSSCHRM1TSHRKDM4E | |
| SCHEMBL7338677 | 0.88 | CTSS (0.34) | RENCTSS | |
| SCHEMBL7335353 | 0.86 | REN (0.38) | RENCTSSHSD17B10CHRM1TSHR | |
| SCHEMBL7331654 | 0.85 | RORC (0.34) | CTSS | |
| SCHEMBL7329936 | 0.84 | AVPR1A (0.40) | RENHSD17B10CHRM1AVPR1ATSHR | |
| SCHEMBL7337426 | 0.83 | REN (0.38) | RENCTSSHSD17B10CHRM1TSHR | |
| SCHEMBL7335478 | 0.81 | AVPR1A (0.38) | RENHSD17B10CHRM1AVPR1ATSHR | |
| SCHEMBL7330956 | 0.79 | REN (0.46) | RENCTSSHSD17B10CHRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |