Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.47 |
| ▸ | BCHE | P06276 | 8/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31297518 | 0.82 | DRD2 (0.54) | ACHEBCHEGRIN1GRIN2AKMT2A | |
| SCHEMBL7336033 | 0.82 | DRD2 (0.54) | ACHEBCHEGRIN1GRIN2AKMT2A | |
| SCHEMBL7332801 | 0.81 | DRD2 (0.52) | ACHEBCHEGRIN1GRIN2AKMT2A | |
| SCHEMBL21122654 | 0.78 | ACHE (0.41) | ACHEBCHEGRIN1GRIN2AGRM2 | |
| SCHEMBL7506685 | 0.77 | ACHE (0.46) | ACHEBCHEGRIN1GRIN2AKMT2A | |
| SCHEMBL10286310 | 0.77 | GRM2 (0.39) | GRM2 | |
| SCHEMBL23181388 | 0.76 | GRM2 (0.71) | GRM2 | |
| SCHEMBL7327581 | 0.75 | DRD2 (0.58) | ACHEGRM2DRD2HTR2A | |
| SCHEMBL16987400 | 0.73 | ACHE (0.43) | ACHEBCHEGRIN1GRIN2AALDH1A1 | |
| SCHEMBL7328659 | 0.72 | DRD2 (0.77) | GRM2DRD2HTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385237-B1 | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO (JP) | 1994-06-29 | — | — | EP | disclosed |
| US-5021421-A | Psychotropic agents | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0385237-A2 | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-09-05 | — | — | EP | disclosed |