Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CALM1 | P0DP23 | 3/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 7/20 | 0.38 |
| ▸ | CNR2 | P34972 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640601 | 0.85 | CYP19A1 (0.53) | CYP19A1CALM1AKR1B1ALDH1A1FGFR1 | |
| SCHEMBL4168797 | 0.83 | ALDH1A1 (0.55) | ALDH1A1MAPK1 | |
| SCHEMBL1911330 | 0.80 | ALDH1A1 (0.42) | CYP19A1CALM1AKR1B1CNR1CNR2 | |
| SCHEMBL8263863 | 0.79 | ALDH1A1 (0.41) | CYP19A1CALM1AKR1B1CNR1CNR2 | |
| SCHEMBL13490827 | 0.79 | MAPK1 (0.41) | CYP19A1CALM1AKR1B1FGFR2ALDH1A1 | |
| SCHEMBL4604574 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MAPK1 | |
| SCHEMBL16956570 | 0.78 | KDM4E (0.48) | ALDH1A1MAPK1 | |
| SCHEMBL12299798 | 0.77 | ALDH1A1 (0.48) | ALDH1A1MAPK1 | |
| SCHEMBL16453478 | 0.77 | CYP19A1 (0.53) | CYP19A1CALM1AKR1B1ALDH1A1FGFR1 | |
| SCHEMBL6481956 | 0.77 | ALDH1A1 (0.52) | CYP19A1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990144-A | TREATING PARKINSON'S DISEASE, TOURETTE'S SYNDROME, SCHIZOPHRENIA, AND ALCOHOL AND DRUG ADDICTION; DOPAMINERGIC PROPERTIES; SIDE-EFFECT REDUCTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-23 | — | — | US | claimed |
| US-5952320-A | USEFUL IN THE TREATMENT OF DISEASES IN WHICH MATRIX METALLOPROTEINASE PLAY A ROLE; MATRIX METALLOPROTEINASE INHIBITING COMPOSITIONS | ABBOTT LABORATORIES (US) | 1999-09-14 | — | — | US | claimed |